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Zinc pyrithione

CAS No. 13463-41-7

Zinc pyrithione ( AI3-62421, BC-J, Biocut ZP, Finecide ZPT, Pyrithione zinc | Zinc pyrithione )

产品货号. M11394 CAS No. 13463-41-7

吡啶硫酮锌是一种抗真菌和抗菌剂,通过阻断质子泵来破坏膜运输。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
500MG ¥365 有现货
1G ¥446 有现货

生物学信息

  • 产品名称
    Zinc pyrithione
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    吡啶硫酮锌是一种抗真菌和抗菌剂,通过阻断质子泵来破坏膜运输。
  • 产品描述
    Zinc pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.(In Vitro):Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM.Zinc Pyrithione (10 nM-10 μM; 72 hours) significantly induces cell death in AAVS1 cells.
  • 体外实验
    Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM. Zinc Pyrithione (10 nM-10 μM; 72 hours) significantly induces cell death in AAVS1 cells.
  • 体内实验
    ——
  • 同义词
    AI3-62421, BC-J, Biocut ZP, Finecide ZPT, Pyrithione zinc | Zinc pyrithione
  • 通路
    Membrane Transporter/Ion Channel
  • 靶点
    Proton Pump
  • 受体
    Proton pump
  • 研究领域
    Cardiovascular Disease
  • 适应症
    ——

化学信息

  • CAS Number
    13463-41-7
  • 分子量
    317.7
  • 分子式
    C10H8N2O2S2Zn
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: 30 mg/mL (94.42 mM)
  • SMILES
    C1=CC2S=[Zn+2]3(S=C4C=CC=CN4[O-]3)[O-]N2C=C1
  • 化学全称
    (T-4)-Bis(1-hydroxy-2(1H)-pyridinethionato-O,S)zinc

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Ermolayeva E, et al. Appl Environ Microbiol, 1995, 61(9), 3385-3390.
产品手册
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