
Zinc pyrithione
CAS No. 13463-41-7
Zinc pyrithione ( AI3-62421, BC-J, Biocut ZP, Finecide ZPT, Pyrithione zinc | Zinc pyrithione )
产品货号. M11394 CAS No. 13463-41-7
吡啶硫酮锌是一种抗真菌和抗菌剂,通过阻断质子泵来破坏膜运输。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
500MG | ¥365 | 有现货 |
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1G | ¥446 | 有现货 |
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生物学信息
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产品名称Zinc pyrithione
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述吡啶硫酮锌是一种抗真菌和抗菌剂,通过阻断质子泵来破坏膜运输。
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产品描述Zinc pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump.(In Vitro):Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM.Zinc Pyrithione (10 nM-10 μM; 72 hours) significantly induces cell death in AAVS1 cells.
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体外实验Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM. Zinc Pyrithione (10 nM-10 μM; 72 hours) significantly induces cell death in AAVS1 cells.
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体内实验——
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同义词AI3-62421, BC-J, Biocut ZP, Finecide ZPT, Pyrithione zinc | Zinc pyrithione
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通路Membrane Transporter/Ion Channel
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靶点Proton Pump
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受体Proton pump
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研究领域Cardiovascular Disease
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适应症——
化学信息
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CAS Number13463-41-7
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分子量317.7
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分子式C10H8N2O2S2Zn
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纯度>98% (HPLC)
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溶解度DMSO: 30 mg/mL (94.42 mM)
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SMILESC1=CC2S=[Zn+2]3(S=C4C=CC=CN4[O-]3)[O-]N2C=C1
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化学全称(T-4)-Bis(1-hydroxy-2(1H)-pyridinethionato-O,S)zinc
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Ermolayeva E, et al. Appl Environ Microbiol, 1995, 61(9), 3385-3390.
产品手册




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